dbGENVOC, a comprehensive, flexible database framework, developed with an aim to allow potential users to access, query, browse and download clinically relevant somatic and germline variation data from Indian oral cancer patients. This database will store variant calls from various studies that uses massively parallel sequencing to generate genome-scale data. First release of dbGENVOC contains (i) ~24 million somatic and germline variants derived from whole exome sequences of 100 Indian oral cancer patients and whole genome sequences of 5 oral cancer patients from India, (ii) somatic variation data from 220 patient samples drawn from the USA and analyzed by TCGA-HNSCC project and (iii) manually curated variation data of 118 patients from recently published peer-reviewed publications. Variants were identified by the community approved best practice protocol and annotated using multiple analytic pipeline. This repository has the potential to support advances in oral cancer research and will be a major step in moving forward from simply cataloging variants to gain insight into their significance. It is freely available and will be updated frequently with variation data from additional oral cancer patients.
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Pradhan S, Das S, Singh AK, Das C, Basu A, Majumder PP, Biswas NK. dbGENVOC: database of GENomic Variants of Oral Cancer, with special reference to India. Database (Oxford). 2021 May 28;2021:baab034. doi: 10.1093/database/baab034. PMID: 34048545; PMCID: PMC8163239.